Oxycodone, sold under the brand names Roxicodone and OxyContin (which is the extended-release form) among others, is a semi-synthetic opioid used medically for the treatment of moderate to severe pain. The standard oxycodone dosage for moderate to severe pain is a 5–15 mg tablet every four to six hours. Use our oxycodone dosage chart to find the recommended and maximum dosage of oxycodone. For moderate to severe pain, initiate oxycodone at 5-15 mg every 4-6 hours as needed, titrating based on individual patient response while monitoring for side effects. 1 Oxycodone acts on the central nervous system (CNS) to relieve pain. Oxycodone extended-release capsules or tablets should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Used to treat severe and persistent pain that requires an extended treatment period with a daily opioid analgesic and for which alternative treatment options are inadequate. 5 mg every 6 hours as needed. Extended-release tablet: 10 mg every 12 hours. Oxycodone is an opioid medication that takes on pain. It comes in tablet, capsule, or liquid form. Understand the uses, side effects, and precautions. Detailed Oxycodone dosage information for adults and children. Includes dosages for Pain and Chronic Pain; plus renal, liver and dialysis adjustments. The recommended initial dose of Oxycodone is 5 to 15 mg every 4 to 6 hours as needed for pain. The dose should be titrated based on the individual patient's response to their initial dose. Approved for adults and opioid-tolerant patients aged 11+ already taking at least 20mg oxycodone daily. Oxycodone can put you at risk for overdose and death. Even if you take your dose correctly as prescribed, you are at risk for opioid addiction, abuse, and misuse that can lead to death. Ideally, if the severity of pain increases, it may require an increase in Oxycodone tablets’ dosage. The 5mg, 10mg, 20mg, 30mg, or 120mg tables can either be used alone or in combination to achieve effective pain relief.